- Columbia - District Headquarters
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 Address: Matthew J. Perry, Jr. United States Courthouse 901 Richland Street, Suite 1300 Columbia, SC 29201-2328 Phone: (803) 765-5821 Fax: (803) 765-5824 
- Aiken
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 Address: Charles E. Simons, Jr. Federal Court House 223 Park Avenue Southwest Aiken, SC 29801-3857 Phone: (803) 765-5821 Fax: (803) 765-5824 Note: Occupied Only During Term of Court 
- Anderson
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 Address: G. Ross Anderson Jr. Federal Building and United States Courthouse 315 South McDuffie Street Anderson, SC 29624-1606 Phone: (864) 232-1566 Fax: (843) 370-9752 Note: Occupied Only During Term of Court 
- Charleston
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 Address: J. Waties Waring Judicial Center 85 Broad Street, Room 260 Charleston, SC 29401-2202 Phone: (843) 727-4255 Fax: (843) 727-4423 
- Florence
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 Address: McMillan Federal Building 401 West Evans Street, Suite 341 Florence, SC 29501-3460 Phone: (843) 662-0750 Fax: (843) 662-0794 
- Greenville
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 Address: Clement F. Haynsworth Jr. Federal Building 300 East Washington Street, Room 232 Greenville, SC 29601-2852 Phone: (864) 232-1566 Fax: (864) 370-3276 
- Spartanburg
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Address: Donald S. Russell Federal Building and United States Courthouse 201 Magnolia Drive Spartanburg, SC 29306-2355 Phone: (864) 232-1566 Fax: (843) 370-9752 Note: Occupied Only During Term of Court 
